大連理工大學導師：劉文黎 正文

[導師姓名]
劉文黎

[所屬院校]
大連理工大學

[基本信息]
導師姓名：劉文黎
性別：男
人氣指數(shù)：910
所屬院校：大連理工大學
所屬院系：
職稱：館員
導師類型：碩導
招生專業(yè)：

[通訊方式]
電子郵件：wenli@dlut.edu.cn

[個人簡述]
在研項目：
1.國家自然科學基金青年項目（主持人）：利用小分子p53-BH3功能模擬物研究Bcl-2-like/p53二聚體調(diào)控內(nèi)源凋亡的分子機制，2016-2018
2.遼寧省博士啟動基金（主持人），2016-2018
3.校際合作項目（主持人）：具有生物正交反應標記的糖基供體化學合成，2016-2017
發(fā)表論文：
1.LiuY,RenY,CaoY,etal.DiscoveryofaLowToxicityO-GlcNAcTransferase(OGT)InhibitorbyStructure-basedVirtualScreeningofNaturalProducts[J].ScientificReports,2017,7.
2.LiuY,HuangH,LiuM,etal.MicroRNA-24-1suppressesmousehepatomacellinvasionandmetastasisviadirectlytargetingO-GlcNActransferase[J].Biomedicine&Pharmacotherapy,2017,91:731-738.
3.LiuY,HuangH,CaoY,etal.SuppressionofOGTbymicroRNA24reducesFOXA1stabilityandpreventsbreastcancercellsinvasion[J].BiochemicalandBiophysicalResearchCommunications,2017,487(3):755-762.
4.YuboLiu,ZhichaoZhang,TingSong,FurongLiang,MingzhouXie,HongkunSheng.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.BritishJournalofPharmacology,169,1612-1623.
5.YuboLiu,ZhiqiangLi,TingSong,ZuguangXue,ZhichaoZhang.(2013)MechanismsofAnti-leukemicActivityoftheBcl-2HomologyDomain-3MimeticS1.Biomedicine&Pharmacotherapy,67,451-556.
6.YuboLiu，MingzhouXie，TingSong，HongkunSheng,XiaoyanYu,ZhichaoZhang.(2015)AnovelBH3mimeticefficientlyinducesapoptosisinmelanomacellsthroughdirectbindingtoanti-apoptoticBcl-2familyproteins，includingphosphorylatedMcl-1.PigmentCell&MelanomaResearch,28(2):161-170.
7.ZhichaoZhang,YuboLiu,TingSong,ZuguangXue,XiaoyunShen,FurongLiang,YanZhao,ZhiqiangLi,HongkunSheng.(2013)AnantiapoptoticBcl-2familyproteinindexpredictstheresponseofleukaemiccellstothepan-Bcl-2inhibitorS1.BritishJournalofcancer108,1870-1878.
8.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1innon-smallcelllungcancercellsthatphosphorylateBimthroughERK1/2andleadtoitsproteasomaldegradation.JournalofThoracicOncology,8,S1061.
9.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.JournalofThoracicOncology,2013,8,S767.
10.ZhichaoZhang,YanZhao,TingSong,YuboLiu,XiangqianLi,PengchenSu,ShenghuiXie.(2013)StudyofbindingthermodynamicsintheoptimizationofBH3mimetics.ChemicalBiology&DrugDesign,82,4,394-400.
11.TingSong,FurongLiang,ZhichaoZhang,YuboLiu,HongkunSheng,MingzhouXie.(2013)S1killsMCF-7/ADRcellsmorethanMCF-7cells:Aprotectivemechanismofendoplasmicreticulumstress.Biomedicine&Pharmacotherapy,67,451-556
12.TingSong,XilongChang,ZhichaoZhang,YuboLiu,XiaoyunShen.(2012)S1,aNovelPan-BH3Mimetic,InducesApoptosisinMcl-1-OverexpressingCellsThroughBak.JournalofPharmacologicalSciences119,330-340.
13.XingHuang,ChuangWang,SongLi,YuboLiu,ZhichaoZhang.(2014)HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.JournalofFluorescence.24(4),1313-1317.
14.YuboLiu,ZhichaoZhang.Ananti-apoptoticBcl-2familyproteinindexpredictstheresponseofleukemiccellstothepan-Bcl-2inhibitorS1.AACRAnnualMeeting2013.CancerResearch:2013,73,1710.
15.SongT,ChaiG,LiuY,etal.Bcl‐2phosphorylationconfersresistanceonchroniclymphocyticleukaemiacellstotheBH3mimeticsABT‐737,ABT‐263andABT‐199byimpedingdirectbinding[J].Britishjournalofpharmacology,2016,173(3):471-483.
16.Wang,A.,Song,T.,Wang,Z.,Liu,Y.,Fan,Y.,Zhang,Y.,&Zhang,Z.(2016).MechanismofMcl‐1ConformationalRegulationUponSmallMoleculeBindingRevealedbyMolecularDynamicSimulation.Chemicalbiology&drugdesign,87(4),551-561.
17.SongT,ChaiG,LiuY,etal.MechanismofsynergyofBH3mimeticsandpaclitaxelinchronicmyeloidleukemiacells:Mcl-1inhibition[J].EuropeanJournalofPharmaceuticalSciences,2015,70:64-71.
18.Huang,X.,Wang,C.,Li,S.,Liu,Y.,&Zhang,Z.(2014).HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.Journaloffluorescence,24(4),1313-1317.
19.李景煜，劉宇博，宋婷，沈曉云，張志超。（2012）BH3模擬物S1誘導人類白血病細胞株K562凋亡的作用機制。白血病·淋巴瘤2012年21卷第12期
20.邢欣榮，劉宇博，程智逵，伍會?。?008）組蛋白修飾酶對基因轉(zhuǎn)錄的調(diào)控.生理科學進展2008年第39卷第4期

[科研工作]
在研項目：
1.國家自然科學基金青年項目（主持人）：利用小分子p53-BH3功能模擬物研究Bcl-2-like/p53二聚體調(diào)控內(nèi)源凋亡的分子機制，2016-2018
2.遼寧省博士啟動基金（主持人），2016-2018
3.校際合作項目（主持人）：具有生物正交反應標記的糖基供體化學合成，2016-2017
發(fā)表論文：
1.LiuY,RenY,CaoY,etal.DiscoveryofaLowToxicityO-GlcNAcTransferase(OGT)InhibitorbyStructure-basedVirtualScreeningofNaturalProducts[J].ScientificReports,2017,7.
2.LiuY,HuangH,LiuM,etal.MicroRNA-24-1suppressesmousehepatomacellinvasionandmetastasisviadirectlytargetingO-GlcNActransferase[J].Biomedicine&Pharmacotherapy,2017,91:731-738.
3.LiuY,HuangH,CaoY,etal.SuppressionofOGTbymicroRNA24reducesFOXA1stabilityandpreventsbreastcancercellsinvasion[J].BiochemicalandBiophysicalResearchCommunications,2017,487(3):755-762.
4.YuboLiu,ZhichaoZhang,TingSong,FurongLiang,MingzhouXie,HongkunSheng.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.BritishJournalofPharmacology,169,1612-1623.
5.YuboLiu,ZhiqiangLi,TingSong,ZuguangXue,ZhichaoZhang.(2013)MechanismsofAnti-leukemicActivityoftheBcl-2HomologyDomain-3MimeticS1.Biomedicine&Pharmacotherapy,67,451-556.
6.YuboLiu，MingzhouXie，TingSong，HongkunSheng,XiaoyanYu,ZhichaoZhang.(2015)AnovelBH3mimeticefficientlyinducesapoptosisinmelanomacellsthroughdirectbindingtoanti-apoptoticBcl-2familyproteins，includingphosphorylatedMcl-1.PigmentCell&MelanomaResearch,28(2):161-170.
7.ZhichaoZhang,YuboLiu,TingSong,ZuguangXue,XiaoyunShen,FurongLiang,YanZhao,ZhiqiangLi,HongkunSheng.(2013)AnantiapoptoticBcl-2familyproteinindexpredictstheresponseofleukaemiccellstothepan-Bcl-2inhibitorS1.BritishJournalofcancer108,1870-1878.
8.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1innon-smallcelllungcancercellsthatphosphorylateBimthroughERK1/2andleadtoitsproteasomaldegradation.JournalofThoracicOncology,8,S1061.
9.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.JournalofThoracicOncology,2013,8,S767.
10.ZhichaoZhang,YanZhao,TingSong,YuboLiu,XiangqianLi,PengchenSu,ShenghuiXie.(2013)StudyofbindingthermodynamicsintheoptimizationofBH3mimetics.ChemicalBiology&DrugDesign,82,4,394-400.
11.TingSong,FurongLiang,ZhichaoZhang,YuboLiu,HongkunSheng,MingzhouXie.(2013)S1killsMCF-7/ADRcellsmorethanMCF-7cells:Aprotectivemechanismofendoplasmicreticulumstress.Biomedicine&Pharmacotherapy,67,451-556
12.TingSong,XilongChang,ZhichaoZhang,YuboLiu,XiaoyunShen.(2012)S1,aNovelPan-BH3Mimetic,InducesApoptosisinMcl-1-OverexpressingCellsThroughBak.JournalofPharmacologicalSciences119,330-340.
13.XingHuang,ChuangWang,SongLi,YuboLiu,ZhichaoZhang.(2014)HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.JournalofFluorescence.24(4),1313-1317.
14.YuboLiu,ZhichaoZhang.Ananti-apoptoticBcl-2familyproteinindexpredictstheresponseofleukemiccellstothepan-Bcl-2inhibitorS1.AACRAnnualMeeting2013.CancerResearch:2013,73,1710.
15.SongT,ChaiG,LiuY,etal.Bcl‐2phosphorylationconfersresistanceonchroniclymphocyticleukaemiacellstotheBH3mimeticsABT‐737,ABT‐263andABT‐199byimpedingdirectbinding[J].Britishjournalofpharmacology,2016,173(3):471-483.
16.Wang,A.,Song,T.,Wang,Z.,Liu,Y.,Fan,Y.,Zhang,Y.,&Zhang,Z.(2016).MechanismofMcl‐1ConformationalRegulationUponSmallMoleculeBindingRevealedbyMolecularDynamicSimulation.Chemicalbiology&drugdesign,87(4),551-561.
17.SongT,ChaiG,LiuY,etal.MechanismofsynergyofBH3mimeticsandpaclitaxelinchronicmyeloidleukemiacells:Mcl-1inhibition[J].EuropeanJournalofPharmaceuticalSciences,2015,70:64-71.
18.Huang,X.,Wang,C.,Li,S.,Liu,Y.,&Zhang,Z.(2014).HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.Journaloffluorescence,24(4),1313-1317.
19.李景煜，劉宇博，宋婷，沈曉云，張志超。（2012）BH3模擬物S1誘導人類白血病細胞株K562凋亡的作用機制。白血病·淋巴瘤2012年21卷第12期
20.邢欣榮，劉宇博，程智逵，伍會?。?008）組蛋白修飾酶對基因轉(zhuǎn)錄的調(diào)控.生理科學進展2008年第39卷第4期

[教育背景]
大連理工大學夜大學 電子

大連理工大學

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