浙江理工大學(xué)生命科學(xué)學(xué)院導(dǎo)師:錢(qián)程

發(fā)布時(shí)間:2021-11-05 編輯:考研派小莉 推薦訪(fǎng)問(wèn):
浙江理工大學(xué)生命科學(xué)學(xué)院導(dǎo)師:錢(qián)程

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浙江理工大學(xué)生命科學(xué)學(xué)院導(dǎo)師:錢(qián)程 正文


  姓名:錢(qián)程 
  性別:男 
  職稱(chēng):教授 
  所在學(xué)院:生命科學(xué)學(xué)院 

  個(gè)人簡(jiǎn)介:
  錢(qián)程,教授、博士、博士生導(dǎo)師,常務(wù)副所長(zhǎng),浙江省特聘教授(錢(qián)江學(xué)者),浙江省“151人才工程”第一層次人才和高校優(yōu)秀留學(xué)回國(guó)人員。曾是西班牙拉瓦那大學(xué)基因治療研究室主任、教授。

  主要研究方向
  方向1:腫瘤干細(xì)胞及腫瘤發(fā)病機(jī)理
  方向2:腫瘤生物基因治療
  方向3:基因表達(dá)的調(diào)控

  科研項(xiàng)目
  1.國(guó)家自然科學(xué)基金項(xiàng)目,靶向溶瘤腺病毒攜帶非編碼小RNA和治療基因協(xié)同治療癌癥的探索性研究,2009-2011,36萬(wàn)元, 項(xiàng)目負(fù)責(zé)人
  2.國(guó)家863項(xiàng)目,新型溶瘤腺病毒載體靶向介導(dǎo)siRNA簇的研究, 90萬(wàn)元,2006-2009,負(fù)責(zé)人
  3.國(guó)家973項(xiàng)目,靶向性、選擇性基因表達(dá)調(diào)控元件及載體的研究,170萬(wàn)元,2004-2009 ,負(fù)責(zé)人
  4.浙江省科技廳重點(diǎn)項(xiàng)目,新型腺病毒載體系統(tǒng)的開(kāi)發(fā)以及在腫瘤基因治療應(yīng)用研究, 25萬(wàn)元,2006-2008 ,負(fù)責(zé)人

  發(fā)表論文
  發(fā)表SCI論文110余篇,近3年的代表性SCI論文:
  1.Ma L, Liu J, Shen J, Liu L, Wu J, Li W, Luo J, Chen Q, Qian C (通訊作者). Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. Cancer Biol Ther. 2010 Apr 20;9(7). [Epub ahead of print]。
  2.Yin Y, Lin F, Zhuang Q, Liu L, Qian C(通訊作者).. Generation of full-length functional antibody against preS2 of hepatitis B virus in hepatic cells in vitro from bicistrons mediated by gutless adenovirus. BioDrugs. 2009;23(6):391-7.
  3.Hu J, Dong A, Fernandez-Ruiz V, Shan J, Kawa M, Martínez-Ansó E, Prieto J, Qian C (通訊作者). Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res. 2009 Sep 1;69(17):6951-9.
  4.Luo J, Xia Q, Zhang R, Lv C, Zhang W, Wang Y, Cui Q, Liu L, Cai R, Qian C (通訊作者). Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7/IL-24 gene. Clin Cancer Res. 2008 Apr 15;14(8):2450-7
  5.Cui Q, Jiang W, Wang Y, Lv C, Luo J, Zhang W, Lin F, Yin Y, Cai R, Wei P, Qian C (通訊作者). Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Hepatology. 2008 Jan;47(1):105-12.
  6.Pan Q, Liu B, Liu J, Cai R, Liu X, Qian C (通訊作者). Synergistic antitumor activity of XIAP-shRNA and TRAIL expressed by oncolytic adenoviruses in experimental HCC. Acta Oncol. 2008; 47(1):135 – 144..
  7.Zhang W, Cai R, Luo R, Wang Y, Cui Q, Wei X, Zhang H, and Qian C (通訊作者). The oncolytic adenovirus targeting to TERT and RB pathway induced specific and potent anti-tumor efficacy in vitro and in vivo for hepatocellular carcinoma. Cancer Biology & Therapy 2007; 6(11): 1726 – 1732.
  8.Pan QW, Zhong SY, Liu BS, Liu J, Cai R, Wang YG, Liu XY, Qian C (通訊作者). Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirus. Acta Pharmacol Sin. 2007 Dec;28(12):1996-2004. Pan Q, Liu B, Liu J, Cai R, Wang Y, Qian C (通訊作者). Synergistic induction of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying TRAIL. Mol Cell Biochem. 2007 Oct;304(1-2):315-23.
  9.Guan M, Rodriguez-Madoz JR, Alzuguren P, Gomar C, Kramer MG, Kochanek S, Prieto J, Smerdou C, Qian C (通訊作者). Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vector. Cancer Res. 2006 Feb 1;66(3):1620-9.
  10.Schmitz V, Vilanueva H, Raskopf E, Hilbert T, Barajas M, Dzienisowicz C, Gorschluter M, Strehl J, Rabe C, Sauerbruch T, Prieto J, Caselmann WH, Qian C (通訊作者). Increased VEGF levels induced by anti-VEGF treatment are independent of tumor burden in colorectal carcinomas in mice. Gene Ther. 2006 Aug;13(16):1198-205.
  11.Qian C (通訊作者), Liu XY, Prieto J. Therapy of cancer by cytokines mediated by gene therapy approach. Cell Res. 2006 Feb;16(2):182-8。

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