姓名：李小強
性別：男
職稱：副教授
學院：藥學系

李小強，第四軍醫(yī)大學藥理學教研室副教授、副主任，碩士研究生導師，陜西省藥品保健食品審評專家。中國藥理學會、中國生物物理學會和美國生物物理學會會員。1999年畢業(yè)于西安交通大學藥學院，獲學士學位，畢業(yè)后參軍入伍至第四軍醫(yī)大學藥理學教研室工作。2007年6月獲第四軍醫(yī)大學醫(yī)學博士學位（學校首批碩-博連讀生）。2006年4月至2008年6月，赴美國Albany醫(yī)學院心血管科學研究中心進行博士研究生聯(lián)合培養(yǎng)和博士后研究工作。

目前負責國家自然科學基金課題2項、陜西省科技計劃項目1項、分題負責十一五國家“重大新藥創(chuàng)制”課題1項，2009年獲第四軍醫(yī)大學“青年英才支持計劃（第二層次）”研究基金資助；以主要完成人參與其他國家、軍隊、省部級課題10余項。

發(fā)表研究論文43篇，其中SCI收錄期刊20余篇；擔任Journal of Pharmacy and Pharmacology，International Immunopharmacology，《心臟雜志》和《細胞與分子免疫學雜志》等國內外期刊審稿人；申請國家發(fā)明專利2項。

任教以來，主講藥理學、臨床藥理學、臨床藥物治療學等課程，發(fā)表教學論文3篇，主編校內教材1部，參編專著4部，2011年獲第四軍醫(yī)大學“精品教員”稱號；曾多次獲嘉獎，榮立個人“三等功”1次。

研究方向：（ 1）離子通道在相關疾病中調控機制的基礎及應用研究；（2）活性天然產物的藥理作用及新藥研究。

發(fā)表的主要文章（*為通訊作者）：
1. Li XQ, Cao W, Zeng AG, Yang ZF, Xing B, Dong L, Zhang HF, Mei QB*. Different pharmacological properties of the optical isomers of MN9202, a novel 1,4-dihydropyridine Ca2+ channel modulator in rat ventricular myocytes. Clin Exp Pharmacol Physiol. 2010;37(8):817-825.
2. Li XQ, Zheng YM, Rathore R, Ma J, Takeshima H, Wang YX*. Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. Pflugers Arch. 2009;457(4): 771-783.
3. Li XQ*, Cao W, Li T, Zeng AG, Hao LL, Zhang XN, Mei QB. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol. 2009;9(9):1032-1041.
4. Li XQ, Zhao MG, Mei QB*, Zhang YF, Guo W, Wang HF, Chen D, Cui Y. Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes. Acta Pharmacol Sin. 2003; 24(12): 1224-1230.
5. Li XQ, Zheng YM, Wang YX*. Functional importance of type-1 ryanodine receptor in smooth muscle cells. Biophysical Journal. 2008, 94(2) : 877-880.
6. Cao W, Li XQ*, Zhang XN, Hou Y, Zeng AG, Xie YH, Wang SW*. Madecassoside suppresses LPS- induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity. Int Immunopharmacol. 2010;10(7):723-729.
7. Cao W, Xie YH, Li XQ*, Zhang XK, Chen YT, Kang R, Chen X, Miao S, Wang SW*. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic Res Cardiol. 2011 Jun 26.
8. Cao W, Li XQ(co-first), Wang X, Li T, Chen X, Liu SB, Mei QB*. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels. Int J Biol Macromol. 2010;46(1):115-122.
9. Cao W, Li XQ(co-first), Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB*. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine. 2010;17(8-9):598-605.
10. Cao W, Li XQ, Liu L, Yang TH, Li C, Fan HT, Jia M, Lv ZG, Mei QB*. Structure of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydr Polymers. 2006;66(2):149-159.
11. Cao W, Li XQ, Liu L, Wang M, Fan HT, Li C, Lv Z, Wang X, Mei Q*. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels. Carbohydr Res. 2006; 341 (11):1870-1877.
12. Rathore R, Zheng YM, Li XQ, Wang QS, Liu QH, Ginnan R, Singer HA, Ho YS, Wang YX*. Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in[Ca2+]i in pulmonary artery smooth muscle cells. Biochem Biophys Res Commun. 2006;351(3):784-790.
13. Liu QH, Zheng YM, Li XQ, Ma JJ, Takeshima H, Wang YX*. PKC epsilon Regulates Calcium Sparks By Selectively Interacting With Type-1 Ryanodine Receptors In Smooth Muscle Cells. Biophysical Journal. 2008, 94(2) : 150-157.
14. Liu QH, Zheng YM, Korde AS, Li XQ, Ma J, Takeshima H, Wang YX*. Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. Am J Respir Cell Mol Biol. 2009; 40(6):663-671.
15. Zhao MG, Mei QB, Zhang YF, Xing B, Li XQ, Cui Y. Inhibitory effects of serotonin on transient outward potassium current in rat ventricular myocytes. Acta Pharmacol Sin. 2002;23(7):617-622.



如果發(fā)現(xiàn)導師信息存在錯誤或者偏差，歡迎隨時與我們聯(lián)系，以便進行更新完善。 聯(lián)系方式