鄭州大學(xué)生物工程系導(dǎo)師:高艷鋒

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鄭州大學(xué)生物工程系導(dǎo)師:高艷鋒

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鄭州大學(xué)生物工程系導(dǎo)師:高艷鋒 正文


  高艷鋒,副教授,碩士生導(dǎo)師。2001年畢業(yè)于蘭州大學(xué)生命科學(xué)學(xué)院生物學(xué)基地班,獲理學(xué)學(xué)士學(xué)位。2006年畢業(yè)于蘭州大學(xué)生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)專業(yè),獲理學(xué)博士學(xué)位。2006年7月進(jìn)入鄭州大學(xué)生命科學(xué)學(xué)院,主要從事腫瘤免疫與多肽藥物研究。河南省生物化學(xué)與分子生物學(xué)會(huì)秘書長(zhǎng),河南省杰出青年基金獲得者,河南省優(yōu)秀中青年骨干教師,鄭州大學(xué)青年骨干教師。Cancer Letters, Bioorganic & Medicinal Chemistry Letters,Peptides,Protein & Peptide Letters和Journal of Food Biochemistry等SCI雜志的審稿人。Chinese Journal of Biology雜志編委。

   承擔(dān)課題:
  [1] 國(guó)家自然科學(xué)基金(81172893)(主持):PD-1/PD-L1拮抗肽的篩選及其在腫瘤免疫治療中的應(yīng)用研究,起止年月:2012年~2015年
  [2] 國(guó)家自然科學(xué)基金(30901362)(主持):乳腺癌PIWIL2、PLAC1抗原HLA-A2限制性CTL表位鑒定以及綜合改造策略研究,起止年月:2010年~2012年
  [3] 河南省杰出青年基金(主持)(134100510015):新型抗腫瘤多肽AS16的研究與開(kāi)發(fā),起止年月:2013年~2015年
  [4] 河南省青年骨干教師資助計(jì)劃(2010GGJS-016)(主持):靶向細(xì)胞周期的新型抗腫瘤多肽的設(shè)計(jì)與活性研究,起止年月:2010年~2012年
  [5] 河南省基礎(chǔ)與前沿技術(shù)項(xiàng)目(102300410077)(主持):基于MazEF復(fù)合物的新型抗菌肽的設(shè)計(jì)、合成與構(gòu)效關(guān)系研究,起止年月:2010年~2012年
  [6] 河南省醫(yī)學(xué)科技攻關(guān)項(xiàng)目(201003008)(主持):基于CT抗原的乳腺癌HLA-A2限制性抗原肽表位的篩選,起止年月:2010年~2012年
  [7] 河南省科技攻關(guān)項(xiàng)目(072102330038)(主持):新型腫瘤抗原肽和廣譜疫苗的研究,起止年月:2007年~2009年
  [8] 河南省醫(yī)學(xué)科技攻關(guān)項(xiàng)目(200703013)(主持):基于Cyclin/CDK復(fù)合物結(jié)構(gòu)的抗腫瘤多肽的研究,起止年月:2007年~2009年
  [9] “十二五”科技部“重大新藥創(chuàng)制”重大專項(xiàng)(2012ZX09103301-023)(副組長(zhǎng)):新型抗腫瘤多肽藥物AS16的研制,起止年月:2012年~2015年
  [10] 河南省重點(diǎn)科技攻關(guān)項(xiàng)目(112102310068)(第2):結(jié)核耐藥相關(guān)抗原CTL表位的篩選與疫苗研制.起止年月:2011年~2013年
  [11] 河南省杰出人才計(jì)劃項(xiàng)目(084200510014)(第2):結(jié)核病抗原肽表位的篩選和多價(jià)疫苗的研制.起止年月:2008年~2010年

  發(fā)表的主要論文:
  [1] Haili Wang, Xi Chen, Yanping Chen, Lei Sun, Guodong Li, Mingxia Zhai, Wenjie Zhai, Qiaozhen Kang, Yanfeng Gao*, Yuanming Qi*.Antitumor activity of novel chimeric peptides derived from cyclinD/CDK4 and the protein transduction domain 4.Amino Acids, 2013, 44(2):499-510.
  [2] Ji Z, Shi X, Liu X, Shi Y, Zhou Q, Liu X, Li L, Ji X, Gao Y, Qi Y, Kang Q.The membrane-cytoskeletal protein 4.1N is involved in the process of cell adhesion, migration and invasion of breast cancer cells.Exp Ther Med.2012, 4(4):736-740.
  [3] Yahong Wu, Yanfeng Gao*, Yujie He, Ranran Shi, Mingxia Zhai, Zongyin Wu, Meng Sun, Wenjie Zhai, Xi Chen, Yuanming Qi*.A novel cytotoxic T lymphocyte epitope analogue with enhanced activity derived from cyclooxygenase-2.Scand J Immunol.2012, 76(3):278-85.
  [4] Chao Dai, Zhaoqing Xu*, Fei Huang, Zhengkun Yu*, Yan-Feng Gao*.Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base Free Conditions.Journal of Organic Chemistry.2012, 77(9):4414-9.
  [5] Fei Chen, Mingxia Zhai, Yuhuang Zhu, Yuanming Qi, Wenjie Zhai, Yanfeng Gao*.In vitro and in vivo identification of a novel cytotoxic T lymphocyte epitope from Rv3425 of Mycobacterium tuberculosis.Microbiology and Immunology.2012, 56(8):548-53.
  [6] Zongyin Wu, Yanfeng Gao*, Yahong Wu, Wei Liu, Meng Sun, Mingxia Zhai, Yuanming Qi, Yong Ye.Identification of a novel CD8+ T cell epitope derived from cancer-testis antigen MAGE-4 in oesophageal carcinoma.Scand J Immunol.2011, 74:561-567.
  [7] Wei Liu, Mingxia Zhai, Zongyin Wu, Yuanming Qi, Yahong Wu, Chao Dai, Meng Sun, Lu Li, Yanfeng Gao* Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer.Amino Acids.2012, 42(6):2257-65.
  [8] Yu-huang Zhu, Yan-feng Gao*, Fei Chen, Wei Liu, Ming-xia Zhai, Wen-jie Zhai, Yuan-ming Qi*, Yong Ye.Identification of novel T cell epitopes from efflux pumps of Mycobacterium tuberculosis.Immunology Letters.2011, 140(1-2):68-73.
  [9] Jun-wei Zhao, Zhan-qiang Sun, Hong-guo Yang, Chong-zhen Zhang and Xiao-li Yu, Zi-lu Wen, Yan-feng Gao, Xiao-kui Guo, Yuan-ming Qi, Shu-lin Zhang.Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis.Annals of Microbiology, 2011, 61(2):345-353.
  [10] Hong Lv, Yan-feng Gao*, Ya-hong Wu, Ming-xia Zhai, Lu Li, Yu-huang Zhu, Wei Liu, Zong-yin Wu, Fei Chen, Yuan-ming Qi.Identification of a novel cytotoxic T lymphocyte epitope from CFP21, a secreted protein of Mycobacterium tuberculosis.Immunology Letters.2010, 133(2):94-8.
  [11] Yanfeng Gao*, Kun Chen, Bin Zhang, Xiang Li, Lu Chen, Yuanjun Li, Xiangjiao Jia, Yongxing Lei, Zhongyi Yan, Liangliang Kong, Nan Wang, Wei Liu, Yuanming Qi.Antioxidant and free radical scavenging activity of the extracellular death factor in Escherichia coli.Peptides, 2010, 31(10):1821-1825.
  [12] Dong-dong Wu, Yan-feng Gao, Li-xiang Chen*, Yuan-ming Qi*, Qiao-zhen Kang, Hai-li Wang, Lin-yu Zhu, Yong Ye, Ming-xia Zhai.Anti-tumor effects of a novel chimeric peptide on S180 and H22 xenografts bearing nude mice.Peptides.2010, 31(5):850-864.
  [13] Yan-feng Gao, Zhan-qiang Sun, Feng Qi, Yuan-ming Qi*, Ming-xia Zhai, Hui-ping Lou, Li-xiang Chen, Yong-xin Li, Xian-yuan Wang.Identification of a new broad-spectrum CD8+ T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma.Cancer Letters, 2009, 284(1):55-61.
  [14] Hui-ping Lou, Yan-feng Gao*, Ming-xia Zhai, Yuan-ming Qi*, Li-xiang Chen, Hong Lv, Ji-bing Yu, Yong-xin Li.A novel peptide from α5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat49–57 with cytotoxic and apoptotic effects against human cancer cells.Bioorganic & Medicinal Chemistry Letters, 2008, 18(16):4633-4637.
  [15] Yan-feng Gao, Ming-xia Zhai, Wei-xia Liu, Xin Liu, Ye Yuan, Yuan-ming Qi*, Rui Wang*.Structure-activity relationships of the dimeric analogues of endomorphin-2 with different lengths of spacers.Protein & Peptide Letters, 2008, 15(3):275-279.
  [16] Chang-Feng Hu, Chuan-Jun Zhu, Yan-Feng Gao, Xuan Shao, Rui Wang, Yu-Xin Cui.Characteristic Fragmentation Behavior of the Analogs of endomorphin-2 with Phenylglycine in Position 3 or 4 by ESI-FT Tandem Mass Spectrometry.Chinese Chemical Letters.2008, 19(12):1479-1482.
  [17] Yun Feng, Ying-wei Lu, Xin Lin, Yan-feng Gao, Qian-yu Zhao, Wei Li, Rui Wang*.Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse.Life Sciences, 2008, 82(13-14):752-763.
  [18] Xuan Shao, Yan-feng Gao, Chuan-jun Zhu, Xue-hui Liu, Jin-long Yao, Yu-xin Cui, Rui Wang*.Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling.Bioorganic & Medicinal Chemistry, 2007, 15(10): 3539-3547.
  [19] Li-xiang Chen, Yuan-ming Qi*, Rui Wang*, Xin Duan, Yan-feng Gao, Ding-jian Yang.Roles of nitric oxide synthase inhibitor on antinociceptive effects of μ-Opioid agonist in mice.Protein & Peptide Letters, 2006, 13(10): 993-997.
  [20] Yan-feng Gao, Xin Liu, Wei-xia Liu, Yuan-ming Qi, Xue-feng Liu, Rui Wang*.Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4.Bioorganic & Medicinal Chemistry Letters, 2006, 16(14):3688-3692.
  [21] Yan-feng Gao, Xin Liu, Jie Wei, Bei-bei Zhu, Qiang Chen, Rui Wang*.Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2.Bioorganic & Medicinal Chemistry Letters, 2005, 15(7):1847-1850.
  [22] Jie Wei, Xuan Shao, Mao-zhen Gong, Bei-bei Zhu, Yu-xin Cui, Yan-feng Gao, Rui Wang*.Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids.Bioorganic & Medicinal Chemistry Letters, 2005, 15(12):2986-2989.
  [23] Yi-feng Zhou, Rui Wang*, Zhao-qing Xu, Wen-jin Yan, Lei Liu, Yan-feng Gao, Chao-shan Da.Boc-L-proline as a new chiral ligand for enantioselective phenylacetylene addition to aromatic aldehydes.Tetrahedron: Asymmetry.2004, 15(4):589-591.
  [24] Xin Lin, Ding-jian Yang, Wen-qing Cai, Qian-yu Zhao, Yan-feng Gao, Qiang Chen, Rui Wang*.Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2003, 1639(3):195-202.

  專利:
  [1] PLAC1抗腫瘤CTL表位肽及其應(yīng)用.專利授權(quán)號(hào):ZL 201010205684.0
  [2] PIWIL2抗腫瘤CTL表位肽及其應(yīng)用.專利授權(quán)號(hào):ZL201010276917.6
  [3] 抗結(jié)核CTL表位肽.專利授權(quán)號(hào):ZL 200910065403.3.
  [4] MAGE-4抗腫瘤CTL表位肽及其應(yīng)用.專利授權(quán)號(hào):ZL201010212512.5
  [5] 結(jié)核分枝桿菌抗原限制性表位肽.專利授權(quán)號(hào):201010030225.3.
  [6] 結(jié)核耐藥相關(guān)外排蛋白來(lái)源抗結(jié)核CTL表位肽及其應(yīng)用.專利授權(quán)號(hào):201110138646.2
  [7] MTA1來(lái)源的抗腫瘤CTL表位肽及其應(yīng)用.專利授權(quán)號(hào):201110138635.4
  [8] PL2L60來(lái)源的CTL表位肽及其應(yīng)用.專利授權(quán)號(hào):201210001557.8

  教材:
  [1] 祁元明主編,高艷鋒,張守濤副主編.生物化學(xué)實(shí)驗(yàn)原理與技術(shù),化學(xué)工業(yè)出版社,2011.普通高等教育“十二五”規(guī)劃教材。
  [2] Understanding Tuberculosis IV: Analyzing the origin of Mycobacterium tuberculosis pathogenicity,InTech Press,2012,參編。

  獲獎(jiǎng)情況:
   [1] 第十一屆中國(guó)國(guó)際多肽會(huì)“Yong Peptide Scientist Award”
   [2] 河南省醫(yī)學(xué)科技進(jìn)步一等獎(jiǎng)和河南省科技進(jìn)步二等獎(jiǎng)
   [3] “沈瓊食管癌研究獎(jiǎng)勵(lì)基金”優(yōu)秀科研成果二等獎(jiǎng)
   [4] 河南省教學(xué)技能大賽二等獎(jiǎng)
   [5] 河南省自然科學(xué)優(yōu)秀論文一等獎(jiǎng)2項(xiàng)
   [6] 河南省自然科學(xué)優(yōu)秀論文二等獎(jiǎng)4項(xiàng)
   [7] 鄭州大學(xué)“三育人”先進(jìn)個(gè)人
   [8] 河南省《生物化學(xué)》教學(xué)團(tuán)隊(duì),主要完成人
   [9] 《生物化學(xué)》校級(jí)精品課程,主要完成人
   [10] 鄭州大學(xué)“挑戰(zhàn)杯”課外學(xué)術(shù)科技競(jìng)賽評(píng)審委員會(huì)委員
   [11] 2007和2010年度鄭州大學(xué)“挑戰(zhàn)杯”活動(dòng)特等獎(jiǎng)和二等獎(jiǎng),指導(dǎo)教師
   [12] 河南省優(yōu)秀碩士學(xué)位論文,指導(dǎo)教師

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