苗登順 ，博士，特聘教授，博士生導(dǎo)師，骨與干細胞研究中心主任。
研究方向：內(nèi)分泌和骨骼生物學(xué)、骨與礦物質(zhì)研究
地址：南京市漢中路140號骨與干細胞研究中心
郵編：210029
電話：025-86862016
E-mail：dsmiao@njmu.edu.cn

個人簡介：
苗登順 男，1954年生，博士、特聘教授、博士生導(dǎo)師，Journal of Bone and Mineral Research、Endocrinology、British Journal of Cancer、Biotechnology Progress和Toxicology and Applied Pharmacology雜志審稿人，南京醫(yī)科大學(xué)解剖學(xué)系學(xué)術(shù)帶頭人，骨與干細胞研究中心主任，加拿大McGill大學(xué)醫(yī)學(xué)系兼職教授。博士畢業(yè)于英國 Sheffield大學(xué),博士后訓(xùn)練在加拿大的 McGill大學(xué)完成，師從David Goltzman教授(加拿大皇家院士)。2002至2005年在加拿大McGill大學(xué)擔任助理教授。2005年5月歸國。在過去的5年中，發(fā)表SCI 收錄的英文全文著作32篇，累計影響因子超過200，引用近500次；SCI收錄的英文會議摘要32篇，參編英文論著兩部。苗登順教授利用不同的甲狀旁腺 素，甲狀旁腺素相關(guān)肽及25-1α-羥化酶等基因敲除動物模型進行骨與干細胞生物學(xué)方面的研究。在相關(guān)領(lǐng)域的研究中，其研究水平目前處于國際領(lǐng)先地位。

獲獎情況：
1994　　江蘇省普通高校優(yōu)秀青年骨干教師
1995．1-1996．1 英國皇家協(xié)會信托獎學(xué)金
1996．1-1999．1 英國sheffield大學(xué)獎學(xué)金
1999．7-2002．6 加拿大國立衛(wèi)生研究院職業(yè)獎學(xué)金
2001．10　　美國骨與礦物質(zhì)研究青年學(xué)者獎
2002-2005　　蒙特利爾總醫(yī)院175周年獎學(xué)金

承擔項目和在研資金情況
2009-2012 國家自然科學(xué)基金重點項目160萬
2006-2009 國家自然科學(xué)基金面上項目30萬
2007-2009 江蘇省衛(wèi)生廳基金項目8
2006-2008 江蘇省自然科學(xué)基金重點項目30
2008-2010 教育部博士點基金6
2009-2012 江蘇省自然科學(xué)基金項目10
2005．5: 南醫(yī)大人才引進啟動資金200萬元
2005-2008 國家重點學(xué)科培育點200萬元
2002-2005 鈣調(diào)激素在促進骨形成中的作用機制。蒙特利爾總醫(yī)院科研基金。17．5萬加幣。
2002-2004 維生素D和PTH在調(diào)節(jié)骨代謝和鈣離子平衡中的相互作用。加拿大國立衛(wèi)生研究院。11．5萬加幣．

論文發(fā)表：
1．Cao, G．, Gu, Z．, Ren, Y．, Shu, L．, Tao, C．, Karaplis, A．, Goltzman, D．, and Miao, D． (Corresponding Author) 2009． Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium． Endocrinology 150:561-569．
2．?Zhang, Z．L．, Tong, J．, Lu, R．N．, Scutt, A．M．, Goltzman, D．, and Miao, D．S． (Corresponding Author) 2009． Therapeutic potential of non-adherent BM-derived mesenchymal stem cells in tissue regeneration． Bone Marrow Transplant 43:69-81．
3．Bai, X．, Dinghong, Q．, Miao, D．, Goltzman, D．, and Karaplis, A．C． 2009． Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype． Am J Physiol Endocrinol Metab 296:E79-88．
4．Miao, D．, Su, H．, He, B．, Gao, J．, Xia, Q．, Zhu, M．, Gu, Z．, Goltzman, D．, and Karaplis, A．C． 2008． Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein． Proc Natl Acad Sci U S A 105:20309-20314．
5．Zhou, C．, Lu, F．, Cao, K．, Xu, D．, Goltzman, D．, and Miao, D． (Corresponding Author) 2008． Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice． Kidney Int 74:170-179．
6．Samadfam, R．, Xia, Q．, Miao, D．, Hendy, G．N．, and Goltzman, D． 2008． Exogenous PTH and endogenous 1,25-dihydroxyvitamin D are complementary in inducing an anabolic effect on bone． J Bone Miner Res 23:1257-1266．
7． Liu Z, Miao D, Xia Q, Hermo L, Wing SS 2007 Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis． Dev Dyn 236:2889-2898
8． Kalantari F, Miao D, Emadali A, Tzimas GN, Goltzman D, Vali H, Chevet E,Auguste P 2007 Cellular and molecular mechanisms of abnormal calcification following ischemia-reperfusion injury in human liver transplantation． Mod Pathol 20:357-366
9．Gao J, Tiwari-Pandey R, Samadfam R, Yang Y, Miao D, Karaplis AC, Sairam MR, Goltzman D 2007 Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone． Endocrinology 148:2613-2621
10．Bai X, Miao D, Goltzman D, Karaplis AC 2007 Early lethality in Hyp mice with targeted deletion of Pth gene． Endocrinology 148:4974-4983
11．Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D (Corresponding Author) 2006 Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null alleles． Endocrinology 147:4801-4810
12．Xue Y, Zhang Z, Karaplis AC, Hendy GN, Goltzman D, Miao D (Corresponding Author) 2005 Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice． J Bone Miner Res 20:1766-1777
13．Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D (Corresponding Author) 2005 Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development． Hum Mol Genet 14:1515-1528
14．Miao D, He B, Jiang Y, Kobayashi T, Soroceanu MA, Zhao J, Su H, Tong X, Amizuka N, Gupta A, Genant HK, Kronenberg HM, Goltzman D, Karaplis AC 2005 Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34． J Clin Invest 115:2402-2411
15．Cao MY, Lee Y, Feng N, Li H, Du C, Miao D, Li J, Lee V, Jin H, Wang M, Gu X, Wright JA, Young AH 2005 NK cell activation and tumor infiltration are involved in the antitumor mechanism of Virulizin． Cancer Immunol Immunother 54:229-242
16．Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, Miao D, Huso DL, Arceci RJ 2004 Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG． Genes Dev 18:1035-1046
17．Soroceanu MA, Miao D, Bai XY, Su H, Goltzman D, Karaplis AC 2004 Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis． J Endocrinol 183:203-216
18．Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM 2004 Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro． Endocrinology 145:1376-1385
19．Panda DK, Miao D (Co-first author), Bolivar I, Li J, Huo R, Hendy GN, Goltzman D 2004 Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis． J Biol Chem 279:16754-16766
20．Miao D, Murant S, Scutt N, Genever P, Scutt A 2004 Megakaryocyte-bone marrow stromal cell aggregates demonstrate increased colony formation and alkaline phosphatase expression in vitro． Tissue Eng 10:807-817
21．Miao D, Liu H, Plut P, Niu M, Huo R, Goltzman D, Henderson JE 2004 Impaired endochondral bone development and osteopenia in Gli2-deficient mice． Exp Cell Res 294:210-222
22．Miao D, Li J, Xue Y, Su H, Karaplis AC, Goltzman D 2004 Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice． Endocrinology 145:3554-3562
23．Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D, Karaplis AC 2004 Skeletal abnormalities in Pth-null mice are influenced by dietary calcium． Endocrinology 145:2046-2053
24．Miao D, Bai X, Panda DK, Karaplis AC, Goltzman D, McKee MD 2004 Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice． Bone 34:638-647
25．Goltzman D, Miao D, Panda DK, Hendy GN 2004 Effects of calcium and of the Vitamin D system on skeletal and calcium homeostasis: lessons from genetic models． J Steroid Biochem Mol Biol 89-90:485-489
26．Bai X, Miao D, Li J, Goltzman D, Karaplis AC 2004 Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders． Endocrinology 145:5269-5279
27．Zhou ZF, Peretz Y, Chang Y, Miao DS, Li X, Prud'homme GJ 2003 Intramuscular gene transfer of soluble B7．1/IgG(1) fusion cDNA induces potent antitumor immunity as an adjuvant for DNA vaccination． Cancer Gene Ther 10:491-499
28．Yu R, Yakar S, Liu YL, Lu Y, LeRoith D, Miao D, Liu JL 2003 Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance． Mol Cell Endocrinol 204:31-42
29．Thomas G, Moffatt P, Salois P, Gaumond MH, Gingras R, Godin E, Miao D, Goltzman D, Lanctot C 2003 Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype． J Biol Chem 278:50563-50571
30．Pizzi H, Gladu J, Carpio L, Miao D, Goltzman D, Rabbani SA 2003 Androgen regulation of parathyroid hormone-related peptide production in human prostate cancer cells． Endocrinology 144:858-867
31．Chan GK, Miao D, Deckelbaum R, Bolivar I, Karaplis A, Goltzman D 2003 Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells． Endocrinology 144:5511-5520
32．Bai XY, Miao D (Co-first author), Goltzman D, Karaplis AC 2003 The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency． J Biol Chem 278:9843-9849
33．Miao D, Scutt A 2002 Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage． J Histochem Cytochem 50:333-340
34．Miao D, Scutt A 2002 Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo． BMC Musculoskelet Disord 3:16
35．Miao D, He B, Karaplis AC, Goltzman D 2002 Parathyroid hormone is essential for normal fetal bone formation． J Clin Invest 109:1173-1182
36．Deckelbaum RA, Chan G, Miao D, Goltzman D, Karaplis AC 2002 Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA． J Cell Sci 115:3015-3025
37．Bai X, Miao D (Co-first author), Panda D, Grady S, McKee MD, Goltzman D, Karaplis AC 2002 Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression． Mol Endocrinol 16:2913-2925
38．Panda DK, Miao D (Co-first author), Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D 2001 Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction． Proc Natl Acad Sci U S A 98:7498-7503
39．Panda DK, Miao D, Lefebvre V, Hendy GN, Goltzman D 2001 The transcription factor SOX9 regulates cell cycle and differentiation genes in chondrocytic CFK2 cells． J Biol Chem 276:41229-41236
40．Miao D, Tong XK, Chan GK, Panda D, McPherson PS, Goltzman D 2001 Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway． J Biol Chem 276:32204-32213
41．Miao D, Bai X, Panda D, McKee M, Karaplis A, Goltzman D 2001 Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition． Endocrinology 142:926-939
42．He B, Deckelbaum RA, Miao D, Lipman ML, Pollak M, Goltzman D, Karaplis AC 2001 Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles． Endocrinology 142:2070-2077
43．Erben RG, Scutt AM, Miao D, Kollenkirchen U, Haberey M 1997 Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow． Endocrinology 138:4629-4635
44．Miao D, Skibinski G, James K 1996 The effects of human seminal plasma and PGE2 on mitogen induced proliferation and cytokine production of human splenic lymphocytes and peripheral blood mononuclear cells． J Reprod Immunol 30:97-114

參編著作：
1．Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D and?? Karaplis AC． Skeletal and reproductive abnormalities in pth-null mice． In: Molecular Biology of the Parathyroid． Naveh-Many, Tally (Ed．)． 2005:179-197．
2． D． Goltzman, D． Miao． Alkaline phosphatase． M． L, Ed．, the Encyclopedia of Endocrine Diseases Academic Press/Elsevier, San Diego． 2004; 164-169．

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