沙家豪 ，博士，特聘教授，博士生導(dǎo)師，生殖醫(yī)學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室主任。
研究方向：生殖醫(yī)學(xué)
地址：南京市漢中路140號(hào)江蘇省生殖醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室
郵編：210029
電話：025-86862908

個(gè)人簡(jiǎn)歷：
沙家豪博士，男，1959年5月出生，南京醫(yī)科大學(xué)特聘教授，博士生導(dǎo)師， 生殖醫(yī)學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室（籌）主任和“配子發(fā)生的分子機(jī)制”學(xué)術(shù)帶頭人，科技部 “生殖與發(fā)育重大科學(xué)計(jì)劃”專家組成員、“生殖健康的基礎(chǔ)和臨床研究”教育部創(chuàng)新團(tuán)隊(duì)帶頭人、國(guó)家杰出青年科學(xué)基金獲得者、中國(guó)動(dòng)物學(xué)會(huì)生殖生物學(xué)分會(huì)副 理事長(zhǎng)、江蘇省解剖學(xué)會(huì)理事長(zhǎng)、江蘇省細(xì)胞遺傳學(xué)會(huì)副理事長(zhǎng)、《Asian J Androl》編委、《Chinese Science Bulletin》編委、《生殖醫(yī)學(xué)雜志》常務(wù)編委、《中國(guó)男科雜志》編委、《男科學(xué)報(bào)》編委、《中國(guó)計(jì)劃生育學(xué)雜志》編委和《國(guó)外醫(yī)學(xué)》計(jì)劃生育分冊(cè)常 務(wù)編委；作為首席科學(xué)家主持973計(jì)劃1項(xiàng)，主持973課題2項(xiàng)，其他國(guó)家級(jí)重大課題多項(xiàng)。在國(guó)內(nèi)外SCI收錄雜志發(fā)表論文70余篇，獲部省級(jí)科技進(jìn)步一 等獎(jiǎng)1項(xiàng)、二等獎(jiǎng)2項(xiàng)，三等獎(jiǎng)5項(xiàng)。2002年獲教育部高等學(xué)校骨干教師稱號(hào)，2004年入選為國(guó)家人事部 “新世紀(jì)百千萬(wàn)人才工程國(guó)家級(jí)人選”，2004年國(guó)家杰出青年科學(xué)基金獲得者，2004年被評(píng)為全國(guó)優(yōu)秀教育工作者，2005年獲國(guó)務(wù)院政府特殊津 貼，2007年入選江蘇省“333高層次人才培養(yǎng)工程”中青年科技領(lǐng)軍人才。

社會(huì)兼職：
中國(guó)動(dòng)物學(xué)會(huì)生殖生物學(xué)分會(huì) 副理事長(zhǎng)
江蘇省解剖學(xué)會(huì)　　理事長(zhǎng)
中國(guó)解剖學(xué)會(huì)　　理事
中華醫(yī)學(xué)會(huì)生殖醫(yī)學(xué)分會(huì)　　委員

榮譽(yù)稱號(hào)：
1997年被評(píng)為江蘇省突出貢獻(xiàn)專家；
1998年和2002年入選為江蘇省 "333工程"第二層次培養(yǎng)對(duì)象；
2001年被評(píng)為江蘇省優(yōu)秀科技工作者;
2002年獲教育部高等學(xué)校骨干教師稱號(hào);
2003年獲江蘇省優(yōu)秀碩士生導(dǎo)師稱號(hào);
2004年入選"新世紀(jì)百千萬(wàn)人才工程國(guó)家級(jí)人選"培養(yǎng)對(duì)象;
2004年獲全國(guó)優(yōu)秀教育工作者稱號(hào)；
2005年獲國(guó)務(wù)院“政府特殊津貼”
2007年入選江蘇省“333高層次人才培養(yǎng)工程”中青年科技領(lǐng)軍人才

獲獎(jiǎng)情況：
2009年“精子發(fā)生相關(guān)蛋白質(zhì)組學(xué)研究”獲教育部自然科學(xué)獎(jiǎng)二等獎(jiǎng)? 排名第一
2005年"人類精子發(fā)生相關(guān)基因表達(dá)譜系的構(gòu)建及功能研究"獲中華醫(yī)學(xué)獎(jiǎng)二等獎(jiǎng)? 排名第一
2004年"人類精子發(fā)生相關(guān)基因表達(dá)譜系的構(gòu)建及功能研究"獲江蘇省科技進(jìn)步一等獎(jiǎng)? 排名第一
2000年"睪酮生成酶和轉(zhuǎn)換酶的研究"獲江蘇省科技進(jìn)步三等獎(jiǎng)　排名第一
1997年"睪丸功能相關(guān)基因的研究"國(guó)家計(jì)生委科技進(jìn)步三等獎(jiǎng)　排名第一
1995年"精子抗原分子免疫學(xué)的研究和應(yīng)用"衛(wèi)生部科技進(jìn)步三等獎(jiǎng)　排名第一
1995年"人精子有效抗原基因表達(dá)克隆的研究"江蘇省科技進(jìn)步三等獎(jiǎng)
1992年"精子功能的研究"江蘇省科技進(jìn)步三等獎(jiǎng)　排名第三

承擔(dān)項(xiàng)目：
973項(xiàng)目　精子遺傳信息穩(wěn)定傳遞的分子機(jī)理(2011CB944300)? 2290萬(wàn) 負(fù)責(zé)人 正在進(jìn)行
國(guó)家自然科學(xué)基金重大研究計(jì)劃項(xiàng)目 母源蛋白在早期胚胎組蛋白修飾中的作用(90919014) 60萬(wàn) 負(fù)責(zé)人 正在進(jìn)行
973課題　睪丸精子功能相關(guān)蛋白與疾病(2006CB504002) 595.81 負(fù)責(zé)人 已完成
973課題　生殖健康基礎(chǔ)研究(G1999055901)　330萬(wàn)　負(fù)責(zé)人　已完成
973課題　精子功能的基礎(chǔ)與臨床研究(2006CB944002) 185萬(wàn) PI 已完成
國(guó)家重大基礎(chǔ)研究前期研究專項(xiàng)? NYD-SPn基因功能研究(2004CCA06800) 50萬(wàn) 負(fù)責(zé)人 已完成
國(guó)家杰出青年基金? 生殖生理學(xué)(30425006) 140萬(wàn) 負(fù)責(zé)人 已完成
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目　人類睪丸蛋白質(zhì)的表達(dá)及功能研究(30630030) 160萬(wàn) 負(fù)責(zé)人 已完成
國(guó)家自然科學(xué)基金　人類卵巢發(fā)育相關(guān)基因表達(dá)譜系的構(gòu)建(30170356)　18萬(wàn)　負(fù)責(zé)人　正在進(jìn)行
國(guó)家自然科學(xué)基金　SF-1對(duì)睪酮生成酶的調(diào)節(jié)作用(39770291)　11萬(wàn)　負(fù)責(zé)人　已完成
國(guó)家教育部重點(diǎn)項(xiàng)目　人精子發(fā)生障礙的分子機(jī)理研究　3萬(wàn)　負(fù)責(zé)人　已完成
江蘇省青年科學(xué)基金　反義SF-1轉(zhuǎn)基因?qū)π∈?BQ98036)　15萬(wàn) 負(fù)責(zé)人　已完成
衛(wèi)生部?jī)?yōu)秀青年科技人才專項(xiàng)基金　睪酮生成酶mRNA調(diào)控的研究(96Q74)　1萬(wàn)　負(fù)責(zé)人　已完成
英國(guó)Wellcome Trust “Mechanisms underlying Leydig cell abnormalities in the Testicular Feminised （Tfm） mouse”( A/C874 114)　 ￡4.3萬(wàn) 負(fù)責(zé)人 已完成

近五年發(fā)表論文：
Correspondence author
Huang XY, Sha JH*. Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility. Asian J Androl. 2011 Jan;13(1):18-23. Review
Guo X, Zhao C, Wang F, Zhu Y, Cui Y, Zhou Z, Huo R, Sha J*. Investigation of human testis protein heterogeneity using 2-dimensional electrophoresis. J Androl. 2010 Jul-Aug;31(4):419-29. Epub 2010 Feb 4.
Zhu H, Cui Y, Xie J, Chen L, Chen X, Guo X, Zhu Y, Wang X, Tong J, Zhou Z, Jia Y, Lue YH, Hikim AS, Wang C, Swerdloff RS, Sha J*. Proteomic analysis of testis biopsies in men treated with transient scrotal hyperthermia reveals the potential targets for contraceptive development. Proteomics. 2010 Oct;10(19):3480-93.
Wang N, Zhang P, Guo X, Xie J, Huo R, Wang F, Chen L, Shen J, Zhou Z, Shi Q, Zhao B, Sha J*. Comparative proteome profile of immature rat ovary during primordial follicle assembly and development. Proteomics. 2009 Jul;9(13):3425-34.
Zhao C, Guo XJ, Shi ZH, Wang FQ, Huang XY, Huo R, Zhu H, Wang XR, Liu JY, Zhou ZM, Sha JH*. Role of translation by mitochondrial-type ribosomes during sperm capacitation: an analysis based on a proteomic approach. Proteomics. 2009 Mar;9(5):1385-99.
Guo X, Su B, Zhou Z, Sha J*. Rapid evolution of mammalian X-linked testis microRNAs. BMC Genomics. 2009 Mar 4;10:97.
Yin L, Chung CM, Huo R, Liu H, Zhou C, Xu W, Zhu H, Zhang J, Shi Q, Wong HY, Chen J, Lu Y, Bi Y, Zhao C, Du Y, Ma M, Cai Y, Chen WY, Fok KL, Tsang LL, Li K, Ni Y, Chung YW, Zhou Z, Sha J*, Chan HC*. A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction. Cell Mol Life Sci. 2009 Mar;66(5):900-8
Yin LL, Chung CM, Chen J, Fok KL, Ng CP, Jia RR, Ren X, Zhou J, Zhang T, Zhao XH, Lin M, Zhu H, Zhang XH, Tsang LL, Bi Y, Zhou Z, Mo F, Wong N, Chung YW, Sha J*, Chan HC*. A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis. J Cell Mol Med. 2009 Sep;13(9B):4034-41.
Guo XJ, Zhang P, Huo R, Zhou ZM, Sha JH*. Analysis of the human testis proteome by mass spectrometry and bioinformatics. Proteomics Clin Appl. 2008,2:1651-7
Ma M, Guo X, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R, Sha J*, Zhou Q*. Protein Expression Profile of the Mouse Metaphase-II Oocyte. J Proteome Res. 2008 Sep 20. 7 (11): 4821–4830
Cui Y, Zhu H, Zhu Y, Guo X, Huo R, Wang X, Tong J, Qian L, Zhou Z, Jia Y, Lue YH, Hikim AS, Wang C, Swerdloff RS, Sha J*. Proteomic analysis of testis biopsies in men treated with injectable testosterone undecanoate alone or in combination with oral levonorgestrel as potential male contraceptive. J Proteome Res. 2008 Sep;7(9):3984-93. Epub 2008 Aug 15.
Huo R, He Y, Zhao C, Guo XJ, Lin M, Sha JH*. Identification of human spermatogenesis-related proteins by comparative proteomic analysis: a preliminary study. Fertil Steril. 2008 Oct;90(4):1109-18. Epub 2008 Feb 20
Hu Y, Xing J, Chen L, Guo X, Du Y, Zhao C, Zhu Y, Lin M, Zhou Z, Sha J*. RGS22, A Novel Testis-Specific Regulator of G-protein Signaling Involved in Human and Mouse Spermiogenesis along with GNA12/13 Subunits. Biol Reprod. 2008:79:1021–1029
Zhao C, Huo R, Wang FQ, Lin M, Zhou ZM, Sha JH*. Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril. 2007 Feb;87(2):436-8. Epub 2006 Oct 30
Lu Y, Huo R, Yuan Y, Li J, Shi Q, Sha J*. Human testicular protein NYD-SP16 is involved in sperm capacitation and the acrosome reaction. ?Fertil Steril. 2006 Oct;86 Suppl 4:1228-34. Epub 2006 Sep 11.
Zheng Y, Zhang J, Wang L, Zhou Z, Xu M, Li J, Sha JH*. Cloning and characterization of a novel sperm tail protein, NYD-SP28. Int J Mol Med. 2006 Dec;18(6):1119-25
Zhu YF, Cui YG, Guo XJ, Wang L, Bi Y, Hu YQ, Zhao X, Liu Q, Huo R, Lin M, Zhou ZM, Sha JH*. Proteomic analysis of effect of hyperthermia on spermatogenesis in adult male mice. J Proteome Res. 2006 Sep;5(9):2217-25
Du Y, Huang XY, Li JM, Hu YQ, Zhou ZM, Sha J*. Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility. Fertil Steril 2006;85(6):1852-1854
Lu L, Lin M, Xu M, Zhou ZM, Sha JH*. Gene functional research using polyethylenimine-mediated in vivo gene transfection into mouse spermatogenic cells. Asian J Androl. 2006;8(1):53-59.
Hu YQ, Lu Y, Zhou ZM, Du Y, Xing J, Wang L, Lin M, Sha JH*. Defective expression of Galpha12 in the testes of azoospermia patients and in the spermatozoa with low motility. J Mol Med. 2006 May;84(5):416-424
Huang M, Wang H, Li JM, Zhou Z, Du Y, Lin M, Sha J*. Involvement of ALF in human spermatogenesis and male infertility. Int J Mol Med. 2006 Apr;17(4):599-604
Senior author：
Guo X, Zhang P, Qi Y, Chen W, Chen X, Zhou Z*, Sha J. Proteomic analysis of male 4C germ cell proteins involved in mouse meiosis. Proteomics. 2011 Jan;11(2):298-308. doi: 10.1002/pmic.200900726. Epub 2010 Dec 10.
Wang N, Zhang P, Guo X, Zhou Z*, Sha J. Hnrnpk, a protein differentially expressed in immature rat ovarian development, is required for normal primordial follicle assembly and development. Endocrinology. 2011 Mar;152(3):1024-35. Epub 2010 Dec 29.
Wang L, Chen W, Zhao C, Huo R, Guo XJ, Lin M, Huang XY, Mao YD*, Zhou ZM*, Sha JH. The role of ezrin-associated protein network in human sperm capacitation. Asian J Androl. 2010 Sep;12(5):667-76. Epub 2010 Aug 16.
Wang H, Chen XX, Wang LR, Mao YD*, Zhou ZM*, Sha JH. AF-2364 is a prospective spermicide candidate. Asian J Androl. 2010 May;12(3):322-35.
Guo X, Shen J, Xia Z, Zhang R, Zhang P, Zhao C, Xing J, Chen L, Chen W, Lin M, Huo R, Su B, Zhou Z*, Sha J. Proteomic analysis of proteins involved in spermiogenesis in mouse. J Proteome Res. 2010 Mar 5;9(3):1246-56.
Ma M, Zhou L, Guo X, Lv Z, Yu Y, Ding C, Zhang P, Bi Y, Xie J, Wang L, Lin M, Zhou Z, Huo R*, Sha J, Zhou Q. Decreased cofilin1 expression is important for compaction during early mouse embryo development. Biochim Biophys Acta. 2009 Dec;1793(12):1804-10. Epub 2009 Sep 12.
Zhang P, Ni X, Guo Y, Guo X, Wang Y, Zhou Z, Huo R*, Sha J. Proteomic-based identification of maternal proteins in mature mouse oocytes. BMC Genomics. 2009 Aug 3;10:348.
Yu Y, Wu J, Fan Y, Lv Z, Guo X, Zhao C, Zhou R, Zhang Z, Wang F, Xiao M, Chen L, Zhu H, Chen W, Lin M, Liu J, Zhou Z, Wang L, Huo R*, Zhou Q*, Sha J. Evaluation of blastomere biopsy using mouse model indicates the potential high-risk of neurodegenerative disorders in the offspring. Mol Cell Proteomics. 2009 Jul;8(7):1490-500. Epub 2009 Mar 11.
Bi Y, Xu WM, Wong HY, Zhu H*, Zhou ZM, Chan HC, Sha JH. NYD-SP27, a novel intrinsic decapacitation factor in sperm. Asian J Androl. 2009 Mar;11(2):229-39.
Huang XY, Guo XJ, Shen J, Wang YF, Chen L, Xie J, Wang NL, Wang FQ, Zhao C, Huo R, Lin M, Wang XR, Zhou ZM*, Sha JH. Construction of a Proteome Profile and Functional Analysis of the Proteins Involved in the Initiation of Mouse Spermatogenesis. J Proteome Res. 2008 Aug;7(8):3435-46. Epub 2008 Jun 27
Zhang KM, Wang YF, Huo R, Bi Y, Lin M, Sha JH, Zhou ZM*. Characterization of Spindlin1 isoform2 in mouse testis. Asian J Androl. 2008 Sep;10(5):741-8.
Zhang JJ, Wu JD, Huo R, Mao YZ, Lu Y, Guo XJ, Liu JY, Zhou ZM, Huang XY, Sha JH. ERp57 is a potential biomarker for human fertilization capability. Molecular Human Reproduction 2007; 13:(9):633–639

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